Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts

Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts

AIM The multifunctional signal molecule calmodulin kinase II (CaMKII) has been associated with cardiac arrhythmogenesis under conditions where its activity is chronically elevated. Recent studies report that its activity is also acutely elevated during acidosis. We test a hypothesis implicating CaMKII in the arrhythmogenesis accompanying metabolic acidification. METHODS We obtained monophasic...

Metabolic regulation of apoptosis via Ca+/Calmodulin Kinase II (CaMKII)

Background The metabolic state of a cell is an important factor in whether or not it engages its apoptotic machinery. Furthermore, reprogramming energy metabolism is now recognized as a hallmark of cancer; so understanding how metabolism regulates apoptosis is crucial. Recently it has been demonstrated that CaMKII serves as a link between metabolic state and apoptosis [1]. Using the Xenopus lae...

Acute atrial arrhythmogenicity and altered Ca2+ homeostasis in murine RyR2-P2328S hearts

AIMS The experiments explored for atrial arrhythmogenesis and its possible physiological background in recently developed hetero-(RyR2(+/S)) and homozygotic (RyR2(S/S)) RyR2-P2328S murine models for catecholaminergic polymorphic ventricular tachycardia (VT) for the first time. They complement previous clinical and experimental reports describing increased ventricular arrhythmic tendencies assoc...

Activation of calcium/calmodulin-dependent kinase II following bovine rotavirus enterotoxin NSP4 expression

Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

effects of omega-3 oil, on calmodulin kinase ii gene expression in the hippocampus of rat during memory formation